25 Acting Duos Who Have Such Undeniable Chemistry On TV, It's Hard To Believe They'd Never Met Before

    "I believe that we can be extraordinary together rather than ordinary apart."

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    A while back, we asked the BuzzFeed Community which TV actors have the best chemistry. There were so many great responses, and a lot of them included actors who met for the first time on their shows. So, here are some of the best acting duos whose chemistry is so incredible, it's shocking they didn't know each other before:

    1. Sandra Oh and Jodie Comer as Eve and Villanelle on Killing Eve.

    Eve and Villanelle standing back-to-back and Villanelle telling Eve to "just walk"

    2. Sam Heughan and Caitriona Balfe as Jamie and Claire on Outlander.

    Claire and Jamie looking at each other and then putting their foreheads together

    3. Phoebe Dynevor and Regé-Jean Page as Daphne and Simon on Bridgerton.

    Simon saying, "To meet a beautiful woman is one thing, but to meet your best friend in the most beautiful of women is something entirely apart"
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    4. Andy Samberg and Melissa Fumero as Jake and Amy on Brooklyn Nine-Nine.

    Amy gasping and saying, "There's a typo in this crossword puzzle!" And Jake smiling at her

    5. Iain De Caestecker and Elizabeth Henstridge as Fitz and Simmons on Agents of S.H.I.E.L.D.

    Jemma telling Fitz, "You're my best friend in the world," and Fitz replying with, "Yeah, and you're more than that, Jemma"

    6. Hugh Dancy and Mads Mikkelsen as Will and Hannibal on Hannibal.

    Hannibal and Will looking at each other, while Will leans up against a ladder

    7. Zach Braff and Donald Faison as J.D. and Turk on Scrubs.

    Turk telling JD, "Your hook shot knocked you unconscious and I laid down next to you so everybody would think we were chillin'"

    8. Katherine Barrell and Dominique Provost-Chalkley as Nicole and Waverly on Wynonna Earp.

    Nicole telling Waverly, "I've been meaning to introduce myself. I'm Nicole. Nicole Haught"

    9. Ellen Pompeo and Patrick Dempsey as Meredith and Derek on Grey's Anatomy.

    Meredith telling Derek, "I'm gonna try and trust you because I believe that we can be extraordinary together rather than ordinary apart"

    10. Sarah Drew and Jesse Williams as April and Jackson on Grey's Anatomy.

    Jackson telling April, "I love you, April. I always have. I love everything about you. Even the things I don't like, I love. And I want you with me. I love you"

    11. Dan Levy and Noah Reid as David and Patrick on Schitt's Creek.

    Patrick serenading David

    12. Zooey Deschanel and Jake Johnson as Jess and Nick on New Girl.

    Nick and Jess kissing in the hallway of their loft

    13. Christina Applegate and Linda Cardellini as Jen and Judy on Dead to Me.

    Jen and Judy hugging on a couch and saying, "I love you"

    14. Daisy Edgar-Jones and Paul Mescal as Marianne and Connell on Normal People.

    Connell telling Marianne, "You know I love you. And I'm never gonna feel the same way for anyone else

    15. Freddy Carter and Amita Suman as Kaz and Inej on Shadow and Bone.

    Kaz telling Inej, "No Saint ever watched over me. Not like you have"

    16. Dulé Hill and James Roday Rodriguez as Gus and Shawn on Psych.

    Shawn asking Gus if they'll still live next to each other, and Gus saying, "Hell yeah, with a pool going across both of our yards"

    17. Kristen Bell and William Jackson Harper as Eleanor and Chidi on The Good Place.

    Chidi telling Eleanor, "Time means nothing. Jeremy Bearimy, baby"

    18. Jennifer Morrison and Colin O'Donoghue as Emma and Hook on Once Upon a Time.

    Emma and Hook looking at each other in the forest

    19. Melissa Benoist and Katie McGrath as Kara and Lena on Supergirl.

    Kara telling Lena, "You don't have to be afraid. I'm right here. And I'm not going anywhere"

    20. Donald Glover and Danny Pudi as Troy and Abed on Community.

    Troy and Abed singing, "Troy and Abed in the morning"

    21. Amy Poehler and Adam Scott as Leslie and Ben on Parks and Rec.

    Ben proposing to Leslie and saying, "I'm thinking about my future. I am deeply ridiculously in love with you"

    22. Stephen Amell and Emily Bett Rickards as Oliver and Felicity on Arrow.

    Felicity and Olivier looking at each other in their first scene together

    23. Indya Moore and Angel Bismark Curiel as Angel and Papi on Pose.

    Papi telling Angel, "You are my dream, and one day, you gonna realize that I'm your man. That I'm gonna protect you and that I'm gonna love you right"

    24. Bob Morley and Eliza Taylor as Bellamy and Clarke on The 100.

    Bellamy and Clarke hugging each other

    25. And finally, Jared Padalecki and Jensen Ackles as Sam and Dean on Supernatural.

    Dean telling Sam, "I'm gonna take care of you. I got you. That's my job, right? Watch after my pain-in-the-ass little brother"

    We can't fit everyone into one post, so which other TV actors who had never met before but have amazing chemistry do you love?

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