Chevy Chase as Clark Griswold
Beverly D'Angelo as Ellen Griswold
What She’s Up To Now: D'Angelo played agent Barbara Miller in HBO's Entourage from 2005 to 2011, and last year, she starred in the post-apocalyptic movie Bounty Killer. Like Chase, D'Angelo is also expected to appear in Vacation.
Doris Roberts as Francis Smith
What She’s Up To Now: Roberts is best known for her role as Raymond's mother on Everybody Loves Raymond. More recently, Roberts guest starred on the ABC Family sitcom Melissa & Joey.
Julia Louis-Dreyfus as Margo Chester
What She’s Up To Now: After playing the Griswolds' snobby neighbor in Christmas Vacation, Louis-Dreyfus went on to star as the iconic Elaine Benes on Seinfeld. She currently stars as U.S. Vice President Selina Meyer on HBO's Veep.
Johnny Galecki as Rusty Griswold
What He’s Up To Now: Like his on-screen mom Ellen, Galecki also appeared on the HBO show Entourage. Since 2007, he has played Dr. Leonard Hofstadter on CBS's The Big Bang Theory, which is now in its eighth season.
Juliette Lewis as Audrey Griswold
Randy Quaid as Cousin Eddie Johnson
Miriam Flynn as Catherine Johnson
What She’s Up To Now: Flynn appeared in the first two seasons of the ABC sitcom Suburgatory. Since 1997, she has voiced the part of Grandma Longneck for The Land Before Time series.
Diane Ladd as Nora Griswold
What She’s Up To Now: A three-time Oscar nominee, Ladd starred in HBO's Enlightened from 2011 to 2013.
Nicholas Guest as Todd Chester
What He’s Up To Now: Guest, who works mainly as a voiceover artist, did voice work for Disney's Tangled and Frozen.