So with such a double whammy, fans have started predicting how their characters are going to leave.
And, because it's Grey's, of course it would make sense for one of them to die.
Most theories are pointing to April's untimely end with a (potentially drunk) car crash.
There are also darker theories pointing towards April killing herself, or having an accidental overdose.
Most theories are pointing towards April dying, because that leaves more room for Jaggie.
As for Arizona, people are predicting she'll probably have a slightly happier exit.
If you or someone you know is going through a rough time, feeling depressed, or thinking about self-harm, you can call the National Suicide Prevention Lifeline at 1-800-273-8255 or visit the website here. If you're based in Australia, you can call Lifeline on 13 11 14 or visit the website here.