🚨Warning: Some major spoilers ahead!🚨
1. On Grey's Anatomy, when Izzie had sex with Denny's ghost.
2. When Betty did a sexy dance at a bar on Riverdale.
3. When Luke and Lorelai broke up and she immediately went and slept with Christopher on Gilmore Girls.
4. When Lexa was killed on The 100.
5. When Joey accidentally proposed to Rachel on Friends.
6. When Marissa was killed on The O.C.
7. When Charlie was trapped underwater on Lost.
8. When Elena was put into a coma on The Vampire Diaries so Bonnie could live.
9. When Michael died unexpectedly on Jane the Virgin.
10. When Michael left on The Office.
11. When Kara and Mon-El got together on Supergirl.
12. When we learned how Jack died on This Is Us.
13. When Carl died on The Walking Dead.
14. When the original students graduated on Glee.
15. After all the characters got a happy ending in Season 6 of Once Upon a Time.
16. When Poussey was killed on Orange Is the New Black.
17. On Scandal, when Olivia was kidnapped and then Fitz went to war in order to get her back.
18. The Red Wedding on Game of Thrones.
19. When Jim and Pam got together on The Office.
20. When Liam almost overdosed on cocaine after getting into Fiona's stash on Shameless.
21. When Dean could talk to dogs on Supernatural.
22. When Luke had a daughter on Gilmore Girls.
23. When Archie formed the Red Circle on Riverdale.
24. On Pretty Little Liars, when it was revealed that CeCe was actually Charles.
25. When Cristina left on Grey's Anatomy.
26. On Dexter, when Dexter found Rita dead in the bathtub.
27. When Matthew and Sybil died on the same season of Downton Abbey.
28. When Leslie and Ben started dating on Parks and Recreation.
29. When the doctors were involved in a plane crash on Grey's Anatomy.
30. When Liza and Charles got together on Younger.
31. When Opie was killed on Sons of Anarchy.
32. On How to Get Away With Murder, when Wes was revealed as the body.
33. When Derek was killed on Grey's Anatomy.
34. When Barney and Robin split up on How I Met Your Mother.
35. When Dan and Blair got together on Gossip Girl.
36. When Lucas and Peyton left on One Tree Hill.
37. When Tyler was assaulted in a school bathroom in Season 2 of 13 Reasons Why.
38. When Grey's Anatomy did a musical episode.
39. When The Walking Dead killed off Glenn.
Note: Some submissions have been edited for length and/or clarity.