Chris Evans (Steve Rogers/Captain America)
What he was best known for in 2006: Playing the Human Torch in the Fantastic Four and Jake in Not Another Teen Movie.
Scarlett Johansson (Natasha Romanoff/Black Widow)
What was she best known for in 2006: Her career-defining role as Charlotte in Lost in Translation.
Don Cheadle (James Rhodes/War Machine)
What was he best known for in 2006: Cheadle was a well-established actor who had starred in films such as Boogie Nights, Traffic, Swordfish, Ocean's Eleven, and Hotel Rwanda.
Jeremy Renner (Hawkeye)
What he was best known for in 2006: Renner had primarily appeared in independent films. He was still three years away from his star-making role in The Hurt Locker.
Sebastian Stan (Bucky Barnes/Winter Soldier)
What he was best known for in 2006: Starring in the horror film The Covenant.
Anthony Mackie (Sam Wilson/Falcon)
What he was best known for in 2006: Playing Shawrelle in Million Dollar Baby and Papa Doc in 8 Mile.
Paul Bettany (Vision)
What was he best known for in 2006: Bettany's biggest roles at the time were playing Geoffrey Chaucer in A Knight's Tale and Charles in A Beautiful Mind. That same year he also appeared as the villainous monk Silas in The Da Vinci Code.
Frank Grillo (Crossbones)
What he was best known for in 2006: Playing Nick Savrinn on Prison Break.
Emily VanCamp (Sharon Carter)
What she was best known for in 2006: Playing Amy Abbott on Everwood.
Paul Rudd (Scott Lang/Ant-Man)
What he was best known for in 2006: At the time Rudd was best known for playing Josh in Clueless, Brian in Anchorman: The Legend of Ron Burgundy, and David in The 40-Year-Old Virgin.
Robert Downey Jr. (Tony Stark/Iron Man)
What he was best known for in 2006: While Downey was a very well-known actor a decade prior (having been an actor since the '80s), he had a series of career setbacks, as well as a well-publicized addiction to drugs. He was still two years away from his comeback role as Tony Stark in Iron Man.