1. One of the main inspirations for The X-Files was the '70s television series Kolchak: The Night Stalker.
2. Creator Chris Carter came up with the idea for The X-Files when he read a report saying 3.7 million people have claimed to have been abducted by aliens.
3. Carter purposely went against established stereotypes by making Agent Fox Mulder a believer and Agent Dana Scully a skeptic.
7. Jodie Foster voiced the talking tattoo in the Season 4 episode "Never Again."
8. According to Carter, Fox Network executives wanted to replace Anderson because they wanted a more "glamorous bombshell" for the part.
11. Before being cast as the Cigarette-Smoking Man, William B. Davis had not smoked a cigarette in 20 years.
12. According to producer Kim Manners, at the start of the show, Davis was only supposed to be an extra leaning against a shelf.
13. Anderson was unhappy with filming a hotel scene in her underwear, where she reveals to Mulder some conspicuous bug bites.
15. Carter said that the test screening for Rupert Murdoch and other Fox executives was met with "spontaneous applause."
16. In 1993, when the show first premiered, Entertainment Weekly responded to The X-Files tagline "The truth is out there" with "We know — This show is a goner."
17. Nicholas Lea, who plays Alex Krycek, actually appears as a completely different character in the Season 1 episode "Gender Bender."
18. The character of Alex Krycek was originally meant to replace Dana Scully for only three episodes, while Anderson was away on maternity leave.
19. X was originally meant to be played by actress Natalija Nogulich from Star Trek: the Next Generation.
She filmed one scene as X before being replaced by Steven Williams. Chris Carter said, "The chemistry wasn't there."
20. Chris Owens, who played the devious Jeffrey Spender, would often receive negative reactions on the street due to his character.
21. Vince Gilligan wrote his first X-Files episode, "Soft Light," as a freelancer. After the success of the episode, he was asked to join the writing staff by Carter.
22. In order to re-create the look of a New Mexico desert in Vancouver, the production crew had to spray over 1,600 gallons of burgundy paint into a gravel pit.
23. Before Season 7, David Duchovny sued 20th Century Fox because he was upset that they had undersold the rights to their own affiliates, thereby costing him lots of money.
24. The show was filmed in Vancouver for the first five seasons before moving to Los Angeles.
The show was originally filmed in Vancouver because, according to Carter, they had to go to "where the good forests are."
25. The show then shifted location from Vancouver to Los Angeles because David Duchovny didn't like the geographical separation from his wife, Tea Leoni.
26. The episode "Home" was the first in the series to receive a viewer discretion warning for graphic content.
27. The episode was also inspired by Charlie Chaplin's autobiography.
28. The episode contains a shot where a sick baby gets buried alive.
29. The Season 1 episode "Tooms" had many "firsts."
Mitch Pileggi appeared for the first time as Walter Skinner, the first time William B. Davis spoke as Cigarette-Smoking Man, and the first time a Monster-of-the-Week character is given a follow-up episode.