Though it's been off the air since 1995, there's been steady buzz about doing a remake, a la the Brady Bunch, with different actors in those iconic roles. John Stamos recently said in The Vulture that he would love to see James Franco strut his stuff as Uncle Jesse. Have mercy indeed. Here's a couple of other suggestions from Buzzfeed.
Nicky and Alex Katsopolis
Add your picks in comments! And hopefully some Hollywood genius will get around to stealing all these great ideas.