Martin Sheen (President Jed Bartlet)
Richard Schiff (Toby Ziegler)
What's he in now? Schiff is starring alongside Lindsay Lohan in the London stage production of Speed-The-Plow until 29 November). He's also in the WGN America drama series Manhattan.
Rob Lowe (Sam Seaborn)
Bradley Whitford (Josh Lyman)
Allison Janney (C.J. Cregg)
Janel Moloney (Donna Moss)
Moira Kelly (Mandy Hampton)
What's she in now? Kelly doesn't have a regular TV or movie gig on the go right now, though there is speculation she may rejoin the cast of the recently announced and much-anticipated return of Twin Peaks (she played Donna Hayward in Twin Peaks: Fire Walk With Me).
Lisa Edelstein (Laurie)
What's she in now? Edelstein will star in the upcoming Bravo TV series Girlfriends' Guide to Divorce.
Deceased: John Spencer (Leo McGarry, died in 2005), Kathryn Joosten (Mrs Landingham, died in 2012)