Stephen Sutton's mother has announced on Facebook the teenager "passed away peacefully in his sleep" on Wednesday morning.
My heart is bursting with pride but breaking with pain for my courageous, selfless, inspirational son who passed away peacefully in his sleep in the early hours of this morning, Wednesday 14th May. The ongoing support and outpouring of love for Stephen will help greatly at this difficult time, in the same way as it helped Stephen throughout his journey. We all know he will never be forgotten, his spirit will live on, in all that he achieved and shared with so many.Love,His mom x
The message received 76,000 comments in half an hour, with people paying tribute to the inspirational teen.
The teenager was diagnosed with bowel cancer at the age of 15 and told two years later it was terminal.
The Teenage Cancer Trust said on Wednesday: “The thoughts of everyone here at Teenage Cancer Trust are with Stephen’s family and friends.
"We are humbled and hugely grateful for what Stephen achieved and continues to achieve for us."
The surge in donations was sparked by numerous celebrities tweeting their support, led by comedian Jason Manford.
One of the items on Sutton's bucket list was "do some public speaking" and in January the teenager received a standing ovation after giving this speech to 4,000 people at the O2 Arena.
Sutton, from Burntwood, Staffordshire, was re-admitted to hospital at the weekend after his condition deteriorated.
Today a number of the politicians and celebrities who supported his campaign paid tribute to him.
Stephen Sutton was the most inspiring person I've ever met and touched more lives than he will ever know.He was an incredibly positive young man and a credit to his family, to Burntwood and to humanity itself. The reason we took to him so passionately was because he was better than us, he did something that none of us could even imagine doing.In his darkest hour he selflessly dedicated his final moments to raising millions of pounds for teenagers with cancer.Some of Stephen's words will stay with me and others forever and they are words to live by - 'life isn't measured in time, it's measured in achievements'.If that's true, Stephen, then you had a fulfilling life full of special moments and you will live long in the memory of thousands, if not millions, of people.