Eminem as Jimmy "B-Rabbit" Smith Jr.
Mehki Phifer as Future
Brittany Murphy as Alex Latourno
Kim Basinger as Stephanie
Anthony Mackie as Papa Doc (Clarence)
Michael Shannon as Greg Buehl
Eugene Byrd as Wink
Omar Benson Miller as Sol George
Evan Jones as Cheddar Bob
De'Angelo Wilson as DJ Iz
Taryn Manning as Janeane
Chloe Greenfield as Lily
UPDATE
After reading some of the comments, there seems to be some confusion. The word "native" is defined as the place or region in which someone was born. That is how it was used in the post.
I hope that clarifies any misunderstanding.