Of course, neither Izzy nor Alex actually appeared in the episode, since Justin left Grey's in the middle of the season and Katherine left the show in the middle of Season 6 in 2010.
"I didn't see it," Katherine admitted, before asking about Alex's relationship status pre-departure: "Wasn't he with someone?"
Then she took it one step further: "Listen, isn't that an asshole move?"
Oh really?
OK! So it sounds like she isn't a fan of that plot line. Got it.
As for whether Katherine — who's currently promoting her role in the Netflix show Firefly Lane — will return to Grey's any time soon? Well: "I'm super focused on this show and my passion for it," she said about Firefly Lane while addressing whether she'd ever throw the scrubs on again. "I would never say never but it's not likely."