She told Entertainment Weekly that Daria is the "only female writer on a late-night talk show" in New York City (though hopefully not only anymore, since it's been five years).
Jane, who also lives in NYC, continues to make art and make fun of everything with Daria, while Trent is still a musician and working as a bartender (also in NYC, though he and Daria never got together).
Quinn still lives in Lawndale and is a divorced influencer with triplets, and Helen and Jake are having a blast being retired.
And Brittany, a weatherperson/cheerleading coach, and Kevin, a stay-at-home dad, are married with five kids.