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Fifty Shades started out as a Twilight fanfic, so the main characters share a lot of similarities.
Fifty Shades: Ana Steele is a clumsy, virginal, bookish brunette with a lip-biting habit who gets completely dazzled by Christian Grey and becomes obsessed with him.
Twilight: Bella Swan is a clumsy, virginal, bookish brunette with a lip-biting habit who gets completely dazzled by Edward Cullen and becomes obsessed with him.
Fifty Shades: José is Ana's good friend who has romantic feelings for her.
Twilight: Jacob is Bella's good friend who has romantic feelings for her.
Fifty Shades: Kate is Ana's confident and beautiful blonde best friend who is in a relationship with Christian's adoptive brother Elliot.
Twilight: Rosalie is Edward's confident and beautiful blonde adoptive sister who is in a relationship with his adoptive brother Emmett.
Fifty Shades: Elliot is Christian's laid-back and fun-loving older adoptive brother who is in a relationship with Kate.
Twilight: Emmett is Edward's laid-back and fun-loving older adoptive brother who is in a relationship with Rosalie.
Fifty Shades: Mia is Christian's bubbly, talented, and outgoing adoptive sister.
Twilight: Alice is Edward's bubbly, talented, and outgoing adoptive sister.
Fifty Shades: Jack Hyde is Ana's boss who gets fired after trying to assault her. He has a history with Christian Grey and stalks him and his family, kidnapping Mia and trying to draw Ana into a trap.
Twilight: James is the leader of a vampire coven who tries to attack Bella. He has a history with Alice Cullen, and he stalks Bella and her family, pretending to kidnap Bella's mother to draw her into a trap.
Fifty Shades: Elena is a family friend who introduced Christian to BDSM as a teenager. She causes trouble for Ana and Christian before being cut off by Christian.
Twilight: Irina is a family friend whose sister Tanya had feelings for Edward. She causes trouble for Bella and Edward before being killed by the Volturi.
Fifty Shades: Grace is Christian's caring adoptive mother. She's a doctor who treated Christian after his biological mother's death.
Twilight: Esme is Edward's caring adoptive mother. She's married to Carlisle, a doctor who turned Edward into a vampire after his biological parents' death.
Fifty Shades: Carrick is the adoptive father of Christian. He's a successful lawyer and businessman.
Twilight: Carlisle is the adoptive father of Edward. He's a successful doctor.
Fifty Shades: Carla is Ana's loving but flighty mother who recently married a guy named Bob.
Twilight: Renee is Bella's loving but flighty mother who recently married a guy named Phil.
Fifty Shades: Elizabeth is in the HR department at Ana's office. She is Jack's accomplice, and plays a part in stalking Ana, Christian, and the Grey family.
Twilight: Victoria is in James' coven and in a relationship with him. She stalks Bella, Edward, and the Cullen family.