America Ferrera as Carmen Lowell
After Sisterhood, America went on to star in the TV series Ugly Betty — the role won her an Emmy and a Golden Globe in 2007. She married Ryan Piers Williams in 2011, and earned her bachelor's degree in international relations in 2013.
Amber Tamblyn as Tibby Rollins
Alexis Bledel as Lena Kaligaris
Blake Lively as Bridget Vreeland
While Blake has continued to act and be flawless, she also launched her own lifestyle website last year. She married Ryan Reynolds in 2012, and once said that Martha Stewart is the only woman who "could creep up on [her] man that [she] would be OK with." She's the first member of the Sisterhood to become a mom.
Jenna Boyd as Bailey Graffman
Since breaking hearts everywhere as Bailey, Jenna's made various television appearances, including roles on Ghost Whisperer and Criminal Minds. According to her Instagram, she's a "Skincare Specialist for Rodan + Fields, lover of red wine, French fries, & being my own boss." She also writes a blog.