1. Mr. Rogers
Mr. Rogers, appearing as himself, comes to visit Elwood City and stays at Arthur’s house. Arthur is embarrassed and doesn’t want his friends to call him a baby.
2. Alex Trebek
Appears as Alex Lebeck, the host of Riddlequest, in the episode “Arthur and the Big Riddle”.
3. Art Garfunkel
Guest stars in “The Ballad of Buster Baxter” as the singing narrator and in “Elwood City Turns 100!” as one of the many guest stars Muffy invites to the play.
4. Larry King
Appearing as himself, King interviews the cast on his show.
5. Michelle Kwan
Appearing as herself, Kwan helps Francine learn to skate.
6. Lance Armstrong
Appearing as Vance Legstrong, he helps the kids with a bike lane petition in “Room to Ride”. He also appears in “The Great MacGrady” where he helps the kids deal with the lunch lady’s cancer diagnosis.
7. Red Sox players Johnny Damon, Mike Timlin, and Edgar Renteria
The Red Sox players appear as members of the fictional baseball team “The Grebes” in “The Curse of the Grebes”.
8. Philip Seymour Hoffman
Appears as William Phillmore Toffman, a famous theater director who returns to Elwood City and directs a show.
9. Astronaut Mike Fincke
Appearing as himself, Fincke helps Buster with his model rocket in “Buster Spaces Out”.
10. Jack Prelutsky, Poet
Appearing as himself, Prelutsky judges the poetry contest at the library.
11. Neil Gaiman
Appearing as himself, Gaiman offers Sue Ellen advice on writing graphic novels.
12. Tom and Ray Magliozzi (of NPR’s “Car Talk”)
Appear as Click and Clack from the Car Talk radio show. Arthur calls them for advice about how to save the family car from the junkyard.
13. Yo-Yo Ma
Yo-Yo Ma, appearing as himself, is asked by D.W. to play at the library.
D.W. incorrectly refers to him as “Yo Mama”.
14. Joshua Redman, Jazz Saxaphonist
In the same episode, Arthur invites Joshua Redman, Francine’s Uncle, to play at the library.
Concerned about the clash between Yo-Yo Ma’s classical music and Redman’s jazz, Arthur imagines the two of them getting into a fight.
15. Matt Damon
Appearing as himself in “The Making of Arthur”, Damon expresses interest in making a show about Arthur’s life.
16. Joan Rivers
Appearing as Francine’s Grandmother, Bubbe, in “Is That Kosher?”, Rivers helps Arthur deal with his grandfather’s Alzheimer’s.
17. The Backstreet Boys
Appearing as themselves, the BackStreet Boys make a guest appearance in the hour long “Arthur: It’s Only Rock ‘N’ Roll”.