Springsteen opened the song announcing to the crowd "I want to send this one out as a letter back home. For justice for Trayvon Martin."
The song was originally written in 2001 in response to the shooting death of Amadou Diallo, a 23-year-old who was shot 41 times by NYPD officers.
The refrain of the song being especially poignant in light of the Trayvon Martin verdict:
Well, is it a gun, is it a knife
Is it a wallet, this is your life
It ain't no secret (it ain't no secret)
No secret my friend
You can get killed just for living in your American skin