The main characters each have varying degrees of talents and even privileges. While Hal, Roxanne, and Metroman are treated much better than Megamind just based off the way they look, they each respond to this in different ways.
Metroman uses his powers to protect the people of Metro City and his wisdom to guide Megamind. In this way, he is using his talents and status for good.
Although Roxanne does not have superpowers, she uses her skills as a reporter to help Metro City. Later on in the movie, she becomes almost like an ally to Megamind, using her privileges and talents to support him as he becomes a hero.
Tighten, however, represents the use of talents in an irresponsible way. Once he gains superpowers, he does not try to help others, like Metroman. Instead, he is very self-serving. While Megamind became a villain because that is the way others treated him, Tighten becomes a villain because he can use his powers to do so.
"All your gifts, all your talents and you squander them for your own personal gain." —Megamind