1. Roseanne Barr as Roseanne Conner
2. John Goodman as Dan Conner
3. Laurie Metcalf as Jackie Harris
4. Sara Gilbert as Darlene Conner
5. Michael Fishman as D.J. Conner
6. Alicia "Lecy" Goranson as Becky Conner
7. Sarah Chalke as Becky Conner
8. Johnny Galecki as David Healy
9. Estelle Parsons as Beverly Harris
10. Martin Mull as Leon Carp
11. Sandra Bernhard as Nancy Bartlett
12. James Pickens Jr. as Chuck Mitchell
Glenn Quinn, who played Mark Healy, passed away in 2002.