1. First, before starring as Tyra Collette on Friday Night Lights, Adrianne Palicki appeared in the pilot as Sam's girlfriend, Jessica.
2. Before playing Jason on The Good Place, Manny Jacinto appeared in Season 8 of Supernatural as a teenager who found a dead body.
3. Solo: A Star Wars Story star Alden Ehrenreich's first acting role was in an episode of Supernatural. He played Ben Collins, the older brother of one of the Wendigo's victims in Season 1.
4. Also, Glee star Cory Monteith appeared in the same episode as Alden. Cory played Gary, a friend of Ben's brother.
5. Before playing Randall Pearson on This Is Us, Sterling K. Brown appeared in several episodes of Supernatural as vampire hunter Gordon Walker.
6. In the same episode as Sterling, Buffy the Vampire Slayer star Amber Benson appeared as the vampire Lenore.
7. Buffy the Vampire Slayer stars James Marsters and Charisma Carpenter reunited for an episode where they played married witches.
