The announcement comes more than two months after Yahoo unveiled revamped email clients on both the web and mobile apps, marking another major change under Mayer's leadership.
Mayer was named CEO last summer after spending years at Google, where she was widely credited with streamlining the company's homepage.
The exec says she adopted a similar approach to Yahoo's page, telling the New York Times that she wanted the site to be "fresh and dynamic" with an "element of surprise and serendipity."
She added that today's unveil is just the "first of many releases," though it may be the most visible. "We're introducing a new way to welcome people to Yahoo," Mayer said.