Unsurprisingly, her opening monologue was packed with jokes.
Amy made a reference to the upcoming midterm elections, jokingly calling them the "midterm abortions" before saying, “Sorry, I was thinking about what’s at stake if we don’t vote. People love giving pregnant women advice, don’t they?"
Amy also talked about how her husband has a diagnosis of Autism Spectrum Disorder, which used to be referred to as Asperger's Syndrome until the name was changed due to Dr. Hans Asperger's ties to the Nazi party in Germany.
After mentioning that fact, Amy not-so-subtly said "Kanye," before receiving laughs and applause from the audience.