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1. The show has an official science advisor (David Saltzberg) who helps the writers with the science portion of the scripts.
2. Mayim Bialik, who plays Dr. Amy Farrah Fowler, is actually a neuroscientist.
3. Despite discussions on the topic, Sheldon Cooper does not have Asperger’s.
4. It's become a "thing" for real scientists to be featured on the show's whiteboard.
5. It took only one take for Cuoco and Galecki to film Penny professing her love for Leonard.
6. The Big Bang writers typically don't plot the season out too far in advance.
7. Galecki and Cuoco (who play Leonard and Penny) actually dated in real life.
8. Leonard is a cellist on the show, but Galecki is a cellist in real life.
9. Co-creator Bill Prady was a computer programmer before entering the entertainment industry.
10. Kevin Sussman (who plays comic shop owner Stuart Bloom) actually worked at a comic book store in New York.
11. A new species of the Brazilian orchid bee was named after Sheldon's catchphrase, "Bazinga!"
12. We will most likely never know Penny's last name.
13. Science enrollment in universities has increased since the show aired.
14. TBBT actually consulted with NASA for Wolowitz's space story line.
15. The show wasn't pitched in a traditional manner.
16. Melissa Rauch imitates her mother's naturally high-pitched voice for her character, Bernadette.
17. The Big Bang Theory is the most watched TV series in America
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