Others said she looked unrecognisable between social media posts.
Some pointed out that her necklace appeared to be missing half of its chain and suggested this was proof the photo had been heavily edited.
And Kris Jenner was loving her daughter's new look.
Khloé, however, didn't respond to the social media furore and instead continued to post promotional photos for Kim, videos of herself working out, and a birthday message for Scott Disick.
But then late last night, Khloé hopped on Instagram again to share a new set of photos — and of course, people had something to say about these, too.
One fan appeared in the comments to ask: "Why do you look so different in all your photos?"
The question amassed over 500 likes, so clearly people were interested. And Khloé wasted no time in responding with a sarcastic comeback.
"From my weekly face transplant clearly," she replied.
Khloé's comment was met with hundreds of responses from fans praising her for the ~clapback~.