Masters of Sex is a show about two researchers in the 1950s–60s who studied human sexual behavior by watching people have sex in real life.
The show is based on the book of the same name by Thomas Maier, who documented the true story of Bill Masters and Virginia Johnson.
Masters was an OB-GYN at Washington University in St. Louis when he met Virginia Johnson, a single mother of two children who took on a role as his research assistant, eventually becoming his partner both professionally and intimately.