21 Iconic TV Roles That Were Almost Played By Different Actors

    Did you know Rob Lowe almost played Derek Shepherd in Grey's Anatomy?

    1. Connie Britton as Olivia Pope in Scandal.

    2. Iwan Rheon as Jon Snow in Game of Thrones.

    3. Courteney Cox as Rachel Green in Friends.

    4. Matthew Broderick as Walter White in Breaking Bad.

    5. Katie Holmes as Buffy Summers in Buffy the Vampire Slayer.

    6. Rob Lowe as Derek Shepherd in Grey's Anatomy.

    7. Octavia Spencer as Donna Meagle in Parks and Rec.

    8. Jennie Garth as Kelly Kapowski in Saved by the Bell.

    9. Rumer Willis as Serena van der Woodsen in Gossip Girl.

    10. Chris Rock as George Costanza in Seinfeld.

    11. Matt LeBlanc as Phil Dunphy in Modern Family.

    12. Jennifer Love Hewitt as Robin Scherbatsky in How I Met Your Mother.

    13. Jaleel White as Rudy Huxtable in The Cosby Show.

    14. Michael Keaton as Jack Shephard in Lost.

    15. Sonequa Martin-Green as Michonne in The Walking Dead.

    16. Rowan Blanchard as Maya Hart and Sabrina Carpenter as Riley Matthews in Girl Meets World.

    17. Adam Scott as Jim Halpert in The Office.

    18. Alicia Silverstone as Angela Chase in My So-Called Life.

    19. Maggie Siff as Peggy Olson in Mad Men.

    20. Alex Borstein as Sookie St. James in Gilmore Girls.

    21. And finally, David Duchovny as either Danny, Joey, or Jesse in Full House.