Arthur could have been very confusing.
Ren & Stimpy would be a little cuter.
SpongeBob SquarePants might have made less sense, or more? I'm not sure.
Pinky and the Brain may have inspired young people everywhere to be animal-rights activists.
The Brave Little Toaster could have been pretty boring.
Chip 'n Dale Rescue Rangers may have focused more on gathering nuts than rescuing.
Chuckie from Rugrats would have been very squeezable.
And Darkwing Duck could have gotten a lot darker.