Roddick took the first set in a tiebreaker and lost the second set in a tiebreaker. Del Potro steamrolled the last two, 6-2, 6-4.
Roddick is the last American to win a Grand Slam event — he won the U.S. Open in 2003.
He's also reached four other Grand Slam finals: Wimbledon in 2004, 2005, and 2009, and the U.S. Open in 2006. Roger Federer beat him each time.
Roddick's also the most recent tennis #1 not named Roger Federer, Rafael Nadal, or Novak Djokovic; he held the honor from 11/3/03 to 2/1/04.
Here, he exchanges words with del Potro, who will advance to face Djokovic in the quarterfinals.
In the stands, Roddick's wife, model Brooklyn Decker, looked on.
Happy trails, Andy Roddick.