Fans are already speculating, though, and it's unlikely that Radio Silence and co. won't want to continue the story they started, which means we'll probably see Melissa Barrera, Jenna Ortega, Jasmin Savoy Brown, and Mason Gooding back as Sam, Tara, Mindy, and Chad, respectively.
As for the remaining legacy cast, that's a harder call to make. It wouldn't really feel like a Scream movie with Sidney Prescott or Gale Weathers, and Neve Campbell obviously agrees, having told ScreenRant she would love to return for another film. It's just a matter of where their story can go following the events of Scream.