Saturday night's performance of Hamilton in New York City was the final time the show's creator and star Lin-Manuel Miranda would take the stage in the title role.
Also ending their run with the show was Leslie Odom Jr. (who won a Tony for his performance as Aaron Burr) and Phillipa Soo (who received a Tony nomination for playing Hamilton's wife, Eliza).
Longtime chorus member Ariana DeBose also took her final bow.
The curtain call was broadcast live on Facebook.
The show's orchestra played a surprise rendition of The West Wing theme as Miranda, who won a Pulitzer for his musical, took his final bow.
Miranda once said Aaron Sorkin's show was one of his inspirations for writing the musical. "West Wing was huge. Like Hamilton, it pulls back the curtain on how decision-making happens at the highest level, or at least how you hope it would be," he told Vulture. "The amount of information Aaron Sorkin packs into a scene gave me this courage to trust the audience to keep up."