If Dan Sullivan topples incumbent Mark Begich, a Democrat, Republicans would pick up another seat in the upper chamber.
"Nobody can remember ever putting these many resources into Alaska before," RNC spokesman Raffi Williams said.
"I find myself unable to look them in the eye without honestly confronting this uncomfortable inequality," moderate Missouri Democrat says.
Even as some political figures are more forthcoming with their support for marriage equality, lawmakers facing tough reelections avoid weighing in.
Red State Democrats already finding themselves in the GOP sights.
"I think they learned their lesson with the debt ceiling," Schumer says.