In the article, they address their lesbian fan base:
"From the beginning, that lively chemistry – along with the fact that the characters can't maintain steady relationships – has some fans wondering whether there was more between Rizzoli and Isles than just dusting for fingerprints. [...] Alexander just smiles. "There's nothing gay about them," she says. "What's gay? That Jane has a raspy voice?" Still. Harmon admits they do play up the tension sometimes. A poster for the new season features the women languidly stretched out together on a picnic blanket, for example. "Sometimes we'll do a take for that demo," Harmon admits. "I'll brush by [Maura's] blouse or maybe linger for a moment. As long as we're not being accused of being homophobic, which is not in any way true and completely infuriating, I'm OK with it."
The title of the spread is "Girlfriends Forever."
Writer Janet Tamaro previously told TV Guide:
The lesbian theory endlessly amuses me, and it amuses the cast. Rizzoli and Isles have been heterosexual from the first episode, though there is no way I would want to interfere with my viewers' fantasy lives.