Peter Griffin, Stewie Griffin, Brian Griffin, Glenn Quagmire; voiced by Seth MacFarlane
Fun Fact: Since he created Family Guy, it makes sense that Seth voices many of the show's characters. Besides Peter, Stewie, Brian and Quagmire, Seth also provides the voices for Carter Pewterschmidt, Dr. Hartman, Ida, Jake Tucker, Jesus, Tom Tucker, Seamus, and more!
Lois Griffin, voiced by Alex Borstein
Fun Fact: You might recognize Alex from MADtv, but on Family Guy, the comedian voices Griffin matriarch Lois as well as Loretta Brown, Barbara Pewterschmidt, and Tricia Takanawa amongst others.
Meg Griffin, voiced by Mila Kunis
Fun Fact: Mila is actually the second person to voice eldest child Meg; Lacey Chabert — most widely known as Gretchen Wieners in Mean Girls — voiced her first.
Chris Griffin, voiced by Seth Green
Fun Fact: On Family Guy, the actor voices middle child Chris Griffin as well as Mort Goldman's son, Neil, and Dylan Flannigan, Brian's son. Seth based Chris' voice on Buffalo Bill's from The Silence of the Lambs!
Cleveland Brown, voiced by Mike Henry
Fun Fact: Yep, Cleveland Brown is voiced by a white dude! And Mike is also the voice of Herbert, Bruce, Consuela, Greased Up Deaf Guy, and more.
Joe Swanson, voiced by Patrick Warburton
Fun Fact: Patrick's mother Barbara has spoken out against the show, saying, "It’s a dichotomy that we have… where [Patrick] wants to do shows and work with people that offend God."
Bonnie Swanson, voiced by Jennifer Tilly
Fun Fact: Jennifer pretty much sounds exactly like Bonnie in real life.
Susie Swanson, voiced by Patrick Stewart
Fun Fact: Yeah, the star of Star Trek and X-Men voices a baby girl's inner monologue. Let that sink in.
Bertram, voiced by Wallace Shawn
Fun Fact: Well, that voice is pretty unmistakeable. Though a constant presence in Hollywood flicks, Wallace has also made appearances on TV shows like Gossip Girl.
Jillian Russell, voiced by Drew Barrymore
Fun Fact: Besides Jillian, Brian's dim-witted ex-girlfriend, Drew also voiced the murderous Mrs. Lockhart from Season 4!
Death, voiced by Adam Carolla
Fun Fact: Death has also been voiced by fellow comedian Norm Macdonald.
Angela, voiced by Carrie Fisher
Fun Fact: Carrie is the daughter of Hollywood royalty Eddie Fisher and Debbie Reynolds! Carrie also appeared as Princess Leia in a little-known franchise called Star Wars.
Mayor Adam West, voiced by Adam West
Fun Fact: Did you know that there was a Batman before Christian Bale? Well there was, and he was played by Adam West.
We originally referred to Mayor Adam West as "Major Adam West" because typing is hard.
Stella, voiced by Marlee Matlin
James Woods, voiced by James Woods
Fun Fact: The show's high school is called James Woods High after the actor!