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    24 "Grey's Anatomy" Plot Twists That Were Genuinely Shocking And Unexpected

    It's a beautiful day to rewatch Grey's Anatomy and cry.

    We recently asked the BuzzFeed Community to tell us the unexpected Grey's Anatomy plot twists that they never saw coming, and boy, did they deliver. Here are some of the best responses.

    Note: Some of the following contain mentions of suicide.

    🚨SPOILERS AHEAD!🚨

    1. Derek being married to Addison in Season 1 when he started his relationship with Meredith.

    ABC / Via youtube.com

    "The original plot twist none of us saw coming!"

    christinet4dde69b6f

    "Are we just gonna forget about the end of Season 1 when Addison came and said, 'And you must be the woman who'd been screwing my husband?'"

    dancing_on_a_cloud

    "Addison's entrance was also one of the greatest plot twists in the show. Everything was going so well for Meredith and Derek, and suddenly, SURPRISE!"

    allisonbway

    Watch the scene here:

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    ABC / Via youtube.com

    2. Alex randomly leaving Jo to raise his two kids with Izzie.

    ABC / Via youtube.com

    "I was furious!!! So much character development, literally 10 years of Alex turning into Mer's person, and he went back to Isobel Stevens 🤬."

    jessica_persinger_1990

    "I knew that Justin Chambers had left the show before the episode aired, but they just did Alex so dirty, and he wouldn’t lie to Jo like that. They had gone with Alex visiting his mom in Iowa to explain his sudden absence. Still, it would’ve made more sense if his mom had gotten worse and he decided to move there to take care of her, or if he got into a car wreck, or literally anything else than what they went with."

    alexfromjupiter

    Watch the scene here:

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    ABC / Via youtube.com

    3. Derek dying after saving several people from a car accident and then being hit by a semi.

    ABC / Via youtube.com

    "The show made it seem like Meredith and Derek were going to break up because they fought the whole Season 11, but at the end, they made up, and he suddenly died. It was more surprising because Patrick Dempsey was signed on until Season 12, so it wasn't expected that he would leave after the producers specially reduced his screen time when he asked for more time for his racing career."

    s4bb472acb

    Watch the scene here:

    View this video on YouTube

    ABC / Via youtube.com

    4. Lexie flirting with Derek in the bar, and then the reveal that she's Meredith's sister.

    ABC / Via youtube.com, ABC / Via youtube.com

    “Lexie Grey is one of my favorite TV characters of all time, and looking back, I always forget that her arrival was such a plot twist. When she flirts with Derek in the bar, I just thought nothing of it, but then she tells George she is a Grey, and I remember just hitting the floor. Honestly, a plot twist that created a perfect TV character.”

    noradominick

    Watch the first scene here:

    View this video on YouTube

    ABC / Via youtube.com

    Derek and Lexie meet at the bar.

    Watch the second scene here:

    View this video on YouTube

    ABC / Via youtube.com

    Meredith meets Lexie and Derek finds out they are sisters.

    5. When Meredith ran away after Derek died and returned to Seattle a year later with a new baby.

    ABC / Via youtube.com

    vidao

    Watch the scene here:

    View this video on YouTube

    ABC / Via youtube.com

    6. When a disfigured patient came into the hospital after being hit by a bus, and Meredith discovered that it was actually George O'Malley, but then he died during surgery.

    ABC / Via youtube.com

    "It absolutely shocked me that John Doe was George, and I have never recovered! The second he wrote 007 in Meredith's hand, my heart was forever broken."

    danielleharper17

    Watch the scene here:

    View this video on YouTube

    ABC / Via youtube.com

    7. Burke returning in Season 10 to give Cristina a job at his hospital in Switzerland.

    ABC / Via youtube.com

    "I was NOT expecting to see Burke in Switzerland, and I know the actor who portrays him has become rather controversial, but bringing him back to give Cristina the 'keys to the kingdom' was the perfect way to end her storyline."

    allisonbway

    Watch the scene here:

    View this video on YouTube

    ABC / Via youtube.com

    8. Penny, aka one of the doctors responsible for Derek's death, coming over for dinner.

    ABC / Via youtube.com

    "Derek's death was hard enough to watch, and I didn't expect to relive it by seeing anyone who was involved in his death ever again. But then Penny came over to Meredith's for dinner, and my jaw was on the floor the entire time. It felt like I was in that dining room and could feel the tension through the screen. IDK which part was more suspenseful to watch, Meredith exposing Penny in front of everyone during dinner, Callie dating Penny, or the fact that Penny then came to work at Grey Sloan Memorial Hospital."

    salimahmccullough

    Watch the scene here:

    View this video on YouTube

    ABC / Via youtube.com

    9. Izzie having sex with the ghost of Denny Duquette.

    ABC / Via youtube.com

    "The show had been so straightforward so far, and that was just really weird."

    rachelsg1210

    Watch the scene here:

    View this video on YouTube

    ABC / Via youtube.com

    10. Alex having a relationship with his patient, Ava.

    ABC / Via youtube.com

    "He’d never been overly attached to patients before, and then for him to have a full-on relationship was so out of character at the time."

    izzywizzyroo

    Watch the scene here:

    View this video on YouTube

    ABC / Via youtube.com

    11. When Meredith, Cristina, Lexie, Derek, Arizona, and Mark were in a plane crash while going to perform surgery, resulting in two deaths and a lost leg.

    ABC / Via youtube.com

    "Especially when everyone believes Mark was fine and safe, then he escalated rapidly and passed, which was heartbreaking."

    carysmcguckin

    Watch the first scene here:

    View this video on YouTube

    ABC / Via youtube.com

    Watch the second scene here:

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    ABC / Via youtube.com

    12. The custody battle for Sofia between Arizona and Callie.

    ABC / Via youtube.com

    "When Callie and Arizona were fighting for custody of Sofia and Arizona won. Especially after rushing out of the courtroom to help her patient."

    olivial4359a9b57

    Watch the scene here:

    View this video on YouTube

    ABC / Via youtube.com

    13. When Gary Clarke decided to initiate the hospital shooting after his wife died there and he believed Derek was to blame.

    ABC / Via youtube.com

    "I never thought they would do something like that! Those two episodes are straight gut punches every single time I watch them. They are difficult episodes to get through, full of their own twists. Including Owen getting shot and Meredith losing her baby."

    littlenatalie

    Watch the scene here:

    View this video on YouTube

    ABC / Via youtube.com

    14. Cristina sending "McWidow," aka Cormac Hayes, as a gift for Meredith.

    ABC / Via youtube.com

    "I know it’s not as big of a moment, but their whole text chain was so funny. Christina kept asking if she got her 'package' and it turned out to be McWidow!"

    b4fe6d2057

    Watch the scene here:

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    ABC / Via youtube.com

    From 0:40 to 1:45.

    15. DeLuca being right about the human trafficking situation.

    ABC / Via youtube.com

    vidao

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    ABC / Via youtube.com

    16. Arizona cheating on Callie with Lauren during the super storm.

    ABC / Via youtube.com

    "I was completely horrified and shocked when Arizona cheated on Callie! I knew that they would break up eventually, but I had no idea why! After I watched it, Callie deserved way better."

    squish37

    Watch the scene here:

    View this video on YouTube

    ABC / Via youtube.com

    17. Meredith finding out that Maggie is Richard's and Ellis's secret love child.

    ABC / Via youtube.com

    "Why has no one mentioned this!? And then Ellis tried to commit suicide!?! Twist after twist. I’m still spinning from that doozy!"

    alisonm40b290f62

    Watch the scene here:

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    ABC / Via youtube.com

    18. Stephanie being trapped in the hospital with the rapist and the little girl and inadvertently blowing up the hospital.

    ABC / Via youtube.com

    "Everything about that episode! When she sprays him with the alcohol rather than stabbing him with the scalpel was brilliant."

    joolzr2

    Watch the scene here:

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    ABC / Via youtube.com

    19. Amelia having a brain tumor.

    ABC / Via youtube.com

    "The fact that it was discovered accidentally during the masturbation study and was used to explain away all of her character flaws and marriage to Owen. 'You married a tumor.'”

    annpricot

    Watch the scene here:

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    ABC / Via youtube.com

    20. Meredith being attacked by a patient.

    ABC / Via youtube.com

    Watch the scene here:

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    ABC / Via youtube.com

    21. When Henry, a sick patient who married Teddy to get on her insurance for his medical care, died.

    ABC / Via youtube.com

    "He was easily the highlight of every episode he was in, and he brought out the best in Teddy."

    alexfromjupiter

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    ABC / Via youtube.com

    Ends at 2:30.

    22. April leaving Matthew at the altar and running away with Jackson.

    ABC / Via youtube.com

    "Definitely a shocker. I still can’t believe she did that."

    vidao

    Watch the scene here:

    View this video on YouTube

    ABC / Via youtube.com

    23. Callie and Arizona getting into a car accident while Callie was pregnant.

    ABC / Via youtube.com

    "I definitely had a 'why Shonda?!' moment."

    alext4e3fc38a7

    Watch the scene here:

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    ABC / Via youtube.com

    24. And last but never least, when Lexie Grey died during the plane crash.

    ABC / Via youtube.com

    "Not just that she died, but how she died. I sob every time I watch that episode. I really thought Mark would find a way to get her out from under the plane, and I expected Lexie to be on the show a lot longer than she was."

    brookej49352887b

    Watch the scene here:

    View this video on YouTube

    ABC / Via youtube.com

    Clearly, we can't fit every twist in this post, so what Grey's Anatomy plots do you believe were the most unexpected and shocking? Tell us in the comments below!

    ABC / Via giphy.com

    Note: Some submissions have been edited for length and/or clarity. Not all submissions were from Community users.

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