Burmese pythons have overrun the Florida everglades, eating smaller species and throwing off the balance of the local ecosystem there.
This Saturday is the opening of the 2013 Python Challenge, a python-killing marathon, offering prizes of $1,000 for catching the longest snakes and $1,500 for catching the most.
The Orlando Sentinel is reporting that nearly 400 people have signed up for the Challenge already.
Participants over the age of 18 do not need hunting licenses or have any experience with snakes.
The Burmese pythons originally entered the ecosystem there through exotic pet trade.
Many experts agree that if enough pythons were eliminated from the area, it could in fact fix some of the damage done to the local environment.
The Florida Wildlife Commission's recommended killing method is a bullet or shotgun blast to the head, or the use of captive bolt, a device used in slaughterhouses that drives a metal shaft into the brain.
The Simpsons eerily predicted this very problem 20 years ago in their episode "Whacking Day":