Michael Kyle played by Damon Wayans
Since the show, Damon Wayans continued to perform stand-up comedy and has an app developing business, MIMS (Money in My Sleep). He's pictured with his son in the photo on the right.
Janet Kyle played by Tisha Campbell-Martin
After the show, Tisha Campbell-Martin continued to act. She played Peaches on Everybody Hates Chris and did some voice acting portraying Beyoncé on Robot Chicken
Junior played by George O. Gore II
After My Wife & Kids ended, George O. Gore continued to act, and even though he's not a Wayans by blood, he's continued to work with the family making an appearance in Dance Flick, did some voiceover work for the cartoon Thugaboo, and appeared in the show Second Generation Wayans.
Claire Kyle played by Jennifer Freeman
After the show, Jennifer continued to act, appearing on various shows like The O.C., One On One, and The Real Husbands Of Hollywood.
Kady Kyle played by Parker McKenna Posey
Since the show Parker has picked up modeling and has continued to act appearing in shows like iCarly, as well as TV movies.
Franklin played by Noah Gray-Cabey
After the show, Noah has continued acting and had a starring role in Lady in the Water, as well as the show Heroes. He's currently enrolled in the Harvard Class of 2016.
Tony Jeffers played by Andrew McFarlane
After the show, Andrew continued to act. He was in the Wayans' Dance Flick and had a recurring role as Jason in The Secret Life of the American Teenager.