After the Lorwardian global invasion, Drakken took a break from his life of crime. But after receiving a call from Professor Dementor bragging about his evil plans, he decided to pick up where he left off as an "evil megalomaniac." While concocting an aging spell planned for Kim Possible to drink, he confused the potion for his coffee and aged himself an extra 15 years. He's permanently retired from evil to raise his family in the hopes that his son will right the many wrongs he has made throughout his career. He prefers to go by his birth name, Drew Theodore P. Lipsky, now.
Shego and Dr. Drakken were regularly attending therapy to smooth out the kinks in their working relationship. Shego started to realize through therapy that she loves Drakken. While coming to that realization, Drakken confessed his love for her. They decided to permanently give up their life of crime to start a family and bully people on various social media websites. She drank some of his aging potion while sarcastically claiming, "That's what an evil sidekick does."
Monique assumed the position of manager at Club Banana in the Middleton Mall. While working there, her favorite wrestler, King Pain, came in to shop for his daughter. She and Pain hit it off instantly and he asked her to become his assistant. She now regularly appears ringside, sometimes participating in wrestling antics on GWA.
After finally being informed by Kim and Ron that he was going to be huge when they time-traveled, Wade decided to take up bodybuilding. Since fighting an evil dictator wasn't in his future, he realized he wouldn't be bulking up the way he did in Kim Possible: A Sitch in Time. At 18 he has made a fortune in designing, creating, and selling the first VR headset for mass consumption. He now beta tests the video games created by various companies for VR headsets and couldn't be happier.
Ron Stoppable completely furnished the pockets in the cargo pants he used to wear in high school so that Rufus could live there and start a family. He owns the Kimmunicator video phone and takes on covert missions from time to time.
After high school Ron Stoppable took it upon himself once again attempt to strictly live off of Bueno Nacho meals. Ned the manager took notice and notified local news stations, and Ron starting receiving national attention almost instantly. He was approached by Guy Fieri to join him on Diners, Drive-Ins and Dives, but Ron declined because he genuinely loves eating Bueno Nacho every day.
Kim announced her retirement from being a freelance hero and assumed Dr. Betty Director's position as leader of the Global Justice Network. She and Ron realized that their end goals in life were far too different and decided to stop dating. They still hang out every day and she often tries to tell him to stop eating Bueno Nacho for every meal but is still unsuccessful in doing so. He often jokes that making him stop would be "Kim Impossible!"