She didn't get it, but in 1988, she starred in Beetlejuice, and then, after that came Thelma & Louise, A League of Their Own, and the list goes on.
8.Zach Galifianakis auditioned in 1999.
He didn't get cast but was hired to guest-write for two weeks, and then was ~dismissed~. After that, he ended up doing Between Two Ferns and then The Hangover, and blah blah blah, it all worked out in the end. Here's a very short clip of his audition: