Jane Sibbett has had limited acting roles since Friends. She was last seen in the 2008 direct-to-video comedy Pretty Little Devils. She now works as a producer with her own production company, Wild Aloha Studios.
Jessica Hecht has gone on to work in film, television, and theater. She was in the recent Broadway production of Harvey, co-starring The Big Bang Theory’s Jim Parsons. Breaking Bad fans will recognize her as Gretchen Schwartz.
James Michael Tyler has made guest appearances on iCarly and Anger Management. Last year he played himself in Episodes — the only Friends actor who would do a cameo for Matt LeBlanc to promote show-within-the-show Pucks.
Maggie Wheeler has been on several sitcoms, including How I Met Your Mother and Curb Your Enthusiasm. Most recently, her iconic voice was heard in four episodes of the FX comedy Archer: she played Trinette.
Vincent Ventresca has acted in many indie films since he played Fun Bobby on Friends (and Billy Christensen in Romy and Michele’s High School Reunion). In 2009, he guest starred in three episodes of Joss Whedon’s Dollhouse.
Lauren Tom is best known for her voiceover work: she is currently the voice of Amy Wong on Futurama. She does live-action work as well. This season on Supernatural, she plays the recurring character of Linda Tran.
Eddie Cahill has played Det. Don Flack on CSI: NY since the show premiered in 2004. That year, he also starred in the hockey film Miracle. Sadly, he is officially off the market: Cahill married longtime girlfriend Nikki Uberti in 2009.
Aisha Tyler is currently one of the co-hosts of The Talk, as well as the voice of Lana on FX’s Archer. She works regularly in TV and film, and as a stand-up comic. She also hosts Girl on Guy, one of iTunes’ top-rated comedy podcasts.
Anna Faris made a name for herself in the Scary Movie series and has gone on to star in several successful comedies, like The House Bunny and What’s Your Number? She recently had her first child with husband Chris Pratt.
Adam Goldberg also appeared in several episodes of the Friends spin-off Joey, but he played a different character. He’s done other indie film and TV work, and he has a band, The Goldberg Sisters. They performed on The Late Late Show in 2011.
Angela Featherstone will have the recurring role of Jame in Season 2 of Girls, premiering this Sunday. In addition to her film and television work, she has contributed pieces to TIME, Jane, and The Huffington Post.
Jon Favreau still acts — he was in the comedies I Love You, Man and Couples Retreat — but he has been very successful as a writer and director. Aside from directing Iron Man and Iron Man 2, he has worked on the NBC series Revolution.
Paget Brewster played Emily Prentiss on Criminal Minds until last year. She has done voice work on King of the Hill and American Dad. Law & Order: SVU fans saw Brewster as Paula Foster in two episodes earlier this season.
Tate Donovan currently stars in the NBC drama Deception. His major TV work includes roles on Damages and The O.C. He also directs TV — he worked behind the camera on Nip/Tuck, Gossip Girl, and Glee.
Michael Rapaport appeared on the series Boston Public, Prison Break, and My Name Is Earl. As a director, he made a documentary about A Tribe Called Quest, Beats, Rhymes & Life. He currently voices Squirt on The Hub’s Pound Puppies series.
Alexandra Holden acts regularly, with recent recurring roles on Franklin & Bash and Rizzoli & Isles. Friday Night Lights fans will remember her as Season 1’s Suzy. She’s also been in several indie films.
Bonnie Somerville starred on short-lived series Kitchen Confidential and Cashmere Mafia. She is also a musician: her song “Winding Road” was on the Garden State soundtrack. Somerville currently sings in Band From TV.
Dermot Mulroney acts and directs. He recently appeared in major films The Grey and Big Miracle, but he also does indie work, like Chris Colfer’s Struck By Lightning. His most recent directorial credit is the romantic comedy Love, Wedding, Marriage.