On April 2, 1931, left-handed pitcher Jackie Mitchell struck out Babe Ruth and Lou Gehrig back-to-back. It only took her seven pitches total.
When Jackie Mitchell was a child, her family lived next to future Hall of Famer Dazzy Vance. Known for his fastball, Vance taught Mitchell how to throw a mean breaking ball when she was only five or six years old.
At 16, Mitchell joined an all-girls team in Chattanooga, Tennessee. Her sinking curveball caught the attention of Joe Engel, owner of the AA Chattanooga Lookouts. He signed her as a pitcher on March 28, 1931.
When Babe Ruth learned he'd be facing a 5'8" girl, he told the New York Times, "I don't know what's going to happen if they begin to let women in baseball. [...] They are too delicate. It would kill them to play ball every day."
The next day, while facing Jackie Mitchell, Babe Ruth whiffed twice and struck out looking. Gehrig went a bit more gracefully, swinging and missing at three consecutive pitches.
After striking out Ruth and Gehrig, Mitchell walked the next batter and was pulled from the game. The Yankees beat the Lookouts 14-4.
The NYT reported on the game, acknowledging that Mitchell was too inexperienced for the majors, but that she should be fine in the minors. The article concluded, "The prospect grows gloomier for misogynists."
Unfortunately, Jackie Mitchell's contract with the Chattanooga Lookouts was voided a few days later, when baseball commissioner Kenesaw Mountain Landis echoed Babe Ruth's bruised ego and claimed the game baseball was "too strenuous" for a woman.