Where: Entabeni Game Reserve, South Africa
When: End of June
Course Info: Intermediate to advanced; dusty terrain and hot, with some killer hills.
Entry Fee: $1,475 for a six-day package
Why it's worth it: This race is named for the five animals' habitats you'll be running through: elephant, rhino, buffalo, lion and leopard. It's all a pretty unique, challenging experience: One runner said, "I felt like I had not only completed another marathon but that I had really acheived something."