Cate Blanchett and Sarah Paulson are also pretty darn good when they combine their unique talents, from Carol to Ocean's 8 to Mrs. America.
And who can forget about Judy Garland and Mickey Rooney and the countless movies they made together in the Old Hollywood days, like the Andy Hardy series and Babes on Broadway. Their chemistry was unmatched!
Whoever it is, we want to know! Tell us the absolute best acting duo of all time (and why you think they're so great) in the comments below.