1. Millie Bobby Brown and David Harbour as Eleven and Hopper on Stranger Things (2016–present):
"Don't even get me started on Millie Bobby Brown and David Harbour on Stranger Things — Hopper (Harbour) took Eleven (Brown) in to protect her. After he 'died' and we saw her walk around after the mall fire/attack looking for him, and ultimately realizing he died, it made me so sad. I was super excited in Stranger Things 4 when we found out that Hopper was alive, and he finally reunited with El. Their chemistry was so, so good."
2. Chadwick Boseman and Letitia Wright as T'Challa/Black Panther and Shuri in Black Panther (2018):
"The first time I watched Black Panther, I knew that Letitia Wright and Chadwick Boseman had amazing onscreen chemistry as Shuri and T'Challa/Black Panther. They played their parts as siblings perfectly, teasing each other as siblings do (but always being there for each other). Black Panther is one of the best portrayals of siblings I have ever seen — I have siblings myself, so it was very relatable. Shuri creating the new suit and taking a video of the joke she played on T'Challa is peak sibling energy. T'Challa knowing Shuri was up to something but going along with it, and Chadwick Boseman's reaction, is how siblings really act with one another. The sarcasm was an accurate portrayal of siblings, and they way they delivered their lines was incredible — they captured true, platonic onscreen chemistry between actors."
3. Mira Sorvino and Lisa Kudrow as Romy White and Michele Weinberger in Romy and Michele's High School Reunion (1997):
"Mira Sorvino and Lisa Kudrow in Romy and Michele's High School Reunion! This movie always had the potential to be great just because of the writing, but casting Lisa Kudrow and Mira Sorvino was the brilliant decision that turned it into the classic it is today. Their chemistry was next level."
4. Chanté Adams and Gbemisola Ikumelo as Max Chapman and Clance Morgan on A League of Their Own (2022):
"Talk about the definition of the best platonic soulmates chemistry on TV. I've only had Max and Clance in my life for a little while, but oh my god, they are the perfect best friends. Chanté and Gbemisola were so funny and wholesome together, and that chemistry just radiated on screen. I mean, Clance telling Max, 'I'm always gonna worry about you, 'cause you're mine' made me weep so hard. They were one of the best parts of A League of Their Own, and it's in part thanks to Chanté and Gbemisola's electric chemistry."
5. Jane Fonda and Lily Tomlin as Grace Hanson and Frankie Bergstein on Grace and Frankie (2015–2022):
"Jane Fonda and Lily Tomlin are two giants in film and TV, and in Grace and Frankie, they bounced off of each other so naturally! And not to mention in real life, they're legit best friends (and funnily enough, Jane is more like Frankie's character and Lily is a bit more reserved)."
6. Regina Hall and Anna Faris as Brenda and Cindy in Scary Movie 2 (2001):
I can watch the Scary Movies over and over again because of Regina Hall and Anna Faris' onscreen chemistry alone. They looked like they worked so well together, and they constantly made us laugh with their quick one-liners and facial expressions — I would do anything for a reunion!
7. Donald Glover and Danny Pudi as Troy Barnes and Abed Nadir on Community (2009–2015):
"The correct answer for best onscreen chemistry is always Troy and Abed from Community. Apparently, they weren't originally supposed to be paired together quite so often, but their incredible chemistry just couldn't be ignored."
8. Steve Martin and Martin Short as George Banks and Franck Eggelhoffer in Father of the Bride (1991):
"Steve Martin and Martin Short! They've always had such fun, witty chemistry in everything they're in together (my favorites are Father of the Bride and Three Amigos). Honestly, if I had an opportunity to do projects with my best friend all the time, I would absolutely do it! You can always tell they're having fun."
9. Kristen Wiig, Melissa McCarthy, Leslie Jones, and Kate McKinnon as Dr. Erin Gilbert, Dr. Abby Yates, Patty Tolan, and Dr. Jillian Holtzmann in Ghostbusters (2016):
This has to be one of the best ensemble casts in movie history! Kristen Wiig, Melissa McCarthy, Leslie Jones, and Kate McKinnon played so well off of each other, and I think that partly has to do with their past collaborations in Bridesmaids (2011) and on Saturday Night Live in the 2000s and 2010s. They were smart, quick-witted, and beyond hilarious, and made this reboot better than anyone ever anticipated.
10. Whitney Houston and Brandy as the Fairy Godmother and Cinderella in Rodgers & Hammerstein's Cinderella (1997):
"No one else could've brought Cinderella and the Fairy Godmother to life in this remake like Brandy and Whitney Houston did. They were so in sync with each other, and their onscreen chemistry was undeniable — that definitely had a lot to do with their friendship offscreen. The behind-the-scenes clip of them rehearsing 'Impossible' in the music studio will forever be magical."
11. Alexis Bledel and Liza Weil as Rory Gilmore and Paris Geller on Gilmore Girls (2000–2007)
"Even when they were fighting as Rory and Paris, their chemistry was amazing."
Alexis and Liza's onscreen chemistry was just as incredible when they reprised their roles as Rory and Paris in Gilmore Girls: A Year in the Life (2016). When their characters returned to Chilton to give inspirational talks to students, they were totally on their A-game. They remained good friends, Paris was in true form, and Rory knew how to calm her down when she spiraled. 10/10 performances.
12. Noah Galvin and Austin Crute as George and Alan in Booksmart (2019):
"Noah Galvin and Austin Crute were so good together as George and Alan in Booksmart that they absolutely deserve their own sequel. That friendship was so believable and unapologetic and funny, and it felt like the actors had already known each other for over a decade. Natural onscreen chemistry like that is so hard to come by, but they killed it (they had me dying throughout the movie). More of them together, please."
13. Tyler Posey and Dylan O'Brien as Scott McCall and Stiles Stilinski on Teen Wolf (2011–2017):
"Tyler Posey and Dylan O’Brien's dynamic on Teen Wolf was amazing. Their chaotic, humorous friendship was an incredible thing to watch — I have NEVER seen a better duo. Plus, they're best friends in real life!!! I love their friendship, both character-wise and offscreen!"
14. Joel Kim Booster and Ron Funches as Nicholas and Howard on Loot (2022–present):
Loot has to be one of the best new TV shows out there. I love me a good ensemble cast, and they totally delivered in their casting — but, no one owns my heart more than Joel Kim Booster and Ron Funches as Nicholas and Howard. Their characters grew so much from Episode 1 through Episode 10, from distant coworkers to best friends, and it was beautiful to watch. Only Joel Kim and Ron could've brought these meaningful, complex, and funny characters to life.
15. Paul Newman and Robert Redford as Shaw and Kelly in The Sting (1973):
"Paul Newman and Robert Redford were incredible in everything they starred in together — from Butch Cassidy and the Sundance Kid (1969) to The Sting (1973). You'd think their 11-year age difference would've created some kind of Old Hollywood rivalry (with Newman being a star for over a decade by then and Redford a newcomer) — however, they were true professionals. You 100% believed their onscreen friendship as Shaw and Kelly — The Sting was a great reunion."
16. Angela Bassett and Whoopi Goldberg as Stella Payne and Delilah Abraham in How Stella Got Her Groove Back (1998):
Angela Bassett and Whoopi Goldberg's chemistry in this '90s classic was unmatched, and every scene they were in together was hilarious, smart, and beyond perfect. I just wish Whoopi Goldberg's character didn't die so soon in the movie — I needed more scenes with them!
17. Alexander Dreymon and Eva Birthistle as Uhtred and Hild on The Last Kingdom (2015–2022):
"I thought Alexander Dreymon and Eva Birthistle had great onscreen chemistry together on The Last Kingdom — their friendship was just so sweet and pure. The scene with Uhtred and Hild after he was rescued was one of the best in the entire series, imo."
18. Colin Morgan and Bradley James as Merlin and Arthur on Merlin (2008–2012):
"Colin Morgan and Bradley James had such fun chemistry together — their friendship, whether they were teasing each other or risking their lives to save the other, was entertaining and wholesome to watch."
19. Sandra Oh and Ellen Pompeo as Cristina Yang and Meredith Grey on Grey's Anatomy (2005–present):
"Their time together on Grey's Anatomy was hilarious and heartfelt and authentic and genuine all at the same time, and it's all because of their onscreen chemistry. They were true to each other, they voiced their opinions when needed, and even through their fights, they'd make sure that the other was okay. I think they're the best!"
20. And Jared Padalecki and Jensen Ackles as Sam and Dean Winchester on Supernatural (2005–2020):
"Jared Padalecki and Jensen Ackles were like lightning in a bottle. You couldn't have had Supernatural without the incredible relationship that they had as brothers (both on and off screen)."
Note: Some submissions have been edited for length and/or clarity.