21 Female Actors Whose Onscreen Chemistry In Movies And TV Was So Amazing They Deserved An Award

    Name a more iconic duo than Jane Fonda and Lily Tomlin. I dare you.

    We asked the BuzzFeed Community to tell us which famous women had the best onscreen chemistry in movies and TV shows. Here are the amazing results.

    Warning: Potential spoilers ahead! 🚨

    1. Sandra Oh and Ellen Pompeo as Cristina and Meredith on Grey's Anatomy (2005–present)

    Cristina telling Meredith Derek isn't the sun -- she is

    2. Regina Hall and Anna Faris as Brenda and Cindy in Scary Movie 2 (2001)

    Cindy yelling at Brenda: "I thought I was your best friend?" and Brenda responding: "Was -- I'm gonna miss you girl!"

    3. Julie Andrews and Anne Hathaway as Queen Clarisse and Mia Thermopolis in The Princess Diaries (2001)

    Clarisse reassuring Mia she was confident all along after giving her speech

    4. Tisha Campbell and Tichina Arnold as Gina and Pam in Martin (1992–1997)

    5. Margot Robbie and Kate McKinnon as Kayla and Jess in Bombshell (2019)

    Jess flirting with Kayla at the bar, telling her she has a really pretty face

    6. Shay Mitchell and Bianca Lawson as Emily and Maya on Pretty Little Liars (2010–2017)

    Emily and Maya taking photo booth pictures together, and ultimately kissing in the last one

    7. Jane Fonda and Lily Tomlin as Grace and Frankie on Grace and Frankie (2015–present)

    Grace telling Frankie how much she loves her, and why she doesn't need to have a gun in the house

    8. Tatiana Maslany and Évelyne Brochu as Cosima and Delphine on Orphan Black (2013–2017)

    Delphine kissing Cosima and saying that she won't let her die

    9. Mary-Louise Parker and Mary Stuart Masterson as Ruth and Idgie in Fried Green Tomatoes (1991)

    10. Angela Bassett and Whoopi Goldberg as Stella and Delilah in How Stella Got Her Groove Back (1998)

    Stella questioning her affair while Delilah responds with: "Do the hympty hump -- fuck him!"

    11. Melissa Fumero and Stephanie Beatriz as Amy and Rosa on Brooklyn Nine-Nine (2013–present)

    Rosa celebrating Amy at the bar for doing out of character dares at her bachelorette party

    12. Jamie Clayton and Freema Agyeman as Nomi and Amanita on Sense8 (2015–2018)

    Amanita and Nomi proposing to each other at the same time

    13. Mira Sorvino and Lisa Kudrow as Romy and Michele in Romy and Michele's High School Reunion (1997)

    Romy and Michele admiring how cute they look in the mirror in their apartment

    14. Jodie Comer and Sandra Oh as Villanelle and Eve on Killing Eve (2018–present)

    Villanelle and Eve staring at each other with deep admiration and tension

    15. Cate Blanchett and Rooney Mara as Carol and Therese in Carol (2015)

    Carol and Therese celebrating New Year's Eve together, looking at each other through the mirror in their hotel room

    16. Whitney Houston and Brandy as Fairy Godmother and Cinderella in Rodgers & Hammerstein's Cinderella (1997)

    17. Maya Erskine and Anna Konkle as Maya and Anna in PEN15 (2019–present)

    Maya crying in the bathroom because she's been labeled as "the ugliest girl" in school, and Anna complimenting her to cheer her up

    18. Kaitlyn Dever and Diana Silvers as Amy and Hope in Booksmart (2019)

    Hope handing Amy a note outside of her home

    19. Amy Poehler and Rashida Jones as Leslie and Anne on Parks and Recreation (2009–2015)

    Anne telling Leslie she's thinking of leaving Pawnee and Leslie reacting in an angry way

    20. Sanaa Lathan and Alfre Woodard as Monica and Camille in Love & Basketball (2000)

    Monica and her mom having a deep conversation about their relationship in the kitchen

    21. And Naya Rivera and Heather Morris as Santana and Brittany on Glee (2009–2015)

    Santana and Brittany singing "Landslide" to each other in a loving and meaningful way

    Note: Submissions were edited for length and/or clarity.

    Which female actors do you think had the best onscreen chemistry in a movie or TV show? Let us know in the comments below!