The eruption happened after a series of earthquakes, the Chilean Interior Ministry reported. The column of smoke and ash rose more than nine miles into the atmosphere.
Shortly after the volcano erupted, Chile's Interior Ministry declared a red alert and ordered evacuations within a 12-mile radius around the volcano.
About 1,500 people were included in the evacuation, the Associated Press reported.
Officials later declared a state of emergency for part of the region, according to the Interior Ministry.
The volcano continued erupting well into the night, with photos capturing lightning in the massive ash cloud.
Wednesday marked the first time Calbuco has erupted in 42 years, the AP reported.
The eruption also comes less than two months after Villarrica, a volcano in central Chile, erupted and forced thousands of people to flee.
Chilean President Michelle Bachelet will visit the affected region Thursday, La Tercera reported.
Jim Dalrymple is a reporter for BuzzFeed News and is based in Los Angeles.
Contact Jim Dalrymple II at firstname.lastname@example.org.
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