Who could forget this classic? After Homer is too sick to take the kids to Duff Gardens, Selma is forced to and this episode was where some of the most memorable Simpsons quotes were born. "I am the LIZARD QUEEN!"

NASA tries to reignite interest in space exploration and pits Barney and Homer against each other for its maiden voyage. Along with "Selma's Choice", this episode is endlessly quotable and features a memorable cameo from Buzz Aldrin.

One of many musical episodes but arguably the most famous. A cameo by Star Trek alum Leonard Nimoy and a hilarious script by Conan O'Brien make this episode a frequent mainstay on "Best Simpsons Episode" lists.