The Fantastic FourThe Justice League of AmericaIron ManThe Avengers
After a cameo in Avengers #54, Ultron made his first appearance in issue #55.
The AvengersThe Justice League of AmericaSupermanWonder Woman
Darkseid first made a cameo in Superman's Pal, Jimmy Olsen #134, then went on to fight Superman as well as his teammates on the Justice League.
Spider-Man was the first superhero to tussle with Wilson Fisk, the Kingpin of Crime. Kingpin first appeared in The Amazing Spider-Man #50.
Spider-ManThe Fantastic FourThe HulkIron Man
Frequent Fantastic Four nemesis Victor von Doom first appeared in Fantastic Four #5.
Circes first battled Wonder Woman in Wonder Woman #37. She also fights Wonder Woman in her first post-Crisis on Infinite Earths appearance.
WolverineThe X-MenIron FistSpider-Man
Sabretooth first clawed his way into comics via Iron Fist #14.
The AvengersThe Fantastic FourThorThe X-Men
Nathaniel Richards first appeared as Rama-Tut in Fantastic Four #19, before popping up under the moniker Kang the Conquerer in The Avengers.
SupergirlGreen LanternJustice League of AmericaMartian Manhunter
Sinestro first turned up in Green Lantern, of course, being one of Green Lantern's main nemeses.
SupergirlOmega MenJustice League of AmericaGreen Lantern
Lobo first appeared in Omega Men #3, a spin-off of Green Lantern and Teen Titans.
The Hypno-Hustler first appeared in the pages of Peter Parker, the Spectacular Spider-Man.
The Teen Titans first battled Deathstroke in their second issue of New Teen Titans.
Wonder WomanCaptain MarvelLokiThor
Enchantress first appeared in Journey into Mystery #103 where she attempted to seduce Thor.
Black Manta first did battle with Aquaman in 1967's Aquaman #35.
The X-MenWolverineMs. MarvelShe-Hulk
Before becoming an X-Men staple, Mystique first appeared opposite Carol Danvers.
Harley first appeared in the animated Batman series, where she fought Batman. But in her first comic appearance, she fought Batgirl!
Can You Match The Comic Book Villain To Their First Fight?
You got crushed!
You barely made it out of this one alive!
You did pretty well, but watch out.