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"In The End, It Screwed Up My Brain,” And 18 Other Things Actors Have Said About Their Most Difficult Roles

"I don’t think you can go through something like this and not have some sort of PTSD afterward."

WARNING: Spoilers ahead!

There are also mentions of sexual assault, eating disorders, and PTSD.

1. Joaquin Phoenix as Arthur Fleck in Joker

Phoenix as the Joker pulling his face into a smile with clown makeup

2. Michael B. Jordan as Killmonger in Black Panther

Jordan as Killmonger

3. Kate Winslet as Hannah in The Reader

Winslet as Hannah riding a bike

4. Natalie Portman as Nina in Black Swan

Natalie as Nina onstage dancing

5. Alex Wolff as Peter in Hereditary

Alex as Peter

6. Ned Beatty as Bobby in Deliverance

Ned as Bobby

7. Janet Leigh as Marion in Psycho

Leigh as Marion in the shower dying

8. Anne Hathaway as Fantine in Les Misérables

Anne as Fantine looking emaciated and sad

9. Bill Skarsgård as Pennywise in It

Bill as Pennywise with a balloon

10. Christina Applegate as Jen on Dead to Me

Jen with a casserole in the dead to me pilot

11. Dakota Johnson as Suzy in Suspiria

Dakota as Suzy

12. Mandy Patinkin as Jason Gideon in Criminal Minds

Mandy as Jason

13. Bob Hoskins as Eddie in Who Framed Roger Rabbit?

Bob Hoskins as Eddie with a toon coming from his chest

14. Kyle Richards as Lindsey in Halloween

Kyle as Lindsey answering the phone

15. Lakeith Stanfield as Bill in Judas and the Black Messiah

Lakeith as Bill

16. Adrien Brody as Władysław Szpilman in The Pianist

Adrien Brody as Władysław Szpilman

17. Jake Gyllenhaal as Lou in Nightcrawler

Jake as Lou outside with a light shining on his body

18. Jim Carrey as Andy Kaufman in Man on the Moon

Carrey as Kaufman

19. And finally, Penn Badgley as Joe in You

Joe with his baby and hat on You

What actors can you think of that struggled to shake certain characters or saw the characters affecting them long after they were done playing them? Let us know in the comments!

The National Eating Disorders Association helpline is 1-800-931-2237; for 24/7 crisis support, text “NEDA” to 741741. The National Alliance on Mental Illness helpline is 1-888-950-6264 (NAMI) and provides information and referral services; GoodTherapy.org is an association of mental health professionals from more than 25 countries who support efforts to reduce harm in therapy. And finally, if you or someone you know has experienced sexual assault, you can call the National Sexual Assault Hotline at 1-800-656-HOPE, which routes the caller to their nearest sexual assault service provider. You can also search your local center here.