Bob Parr/Mr. Incredible, voiced by Craig T. Nelson
Helen Parr/Elastigirl, voiced by Holly Hunter
Where you've heard her voice before: Just like her illustrated husband, the Academy Award-winner's role in The Incredibles is one of her only notable voice acting roles. (She apparently voiced the narrator in a 1989 short titled The Three Billy Goats Gruff and The Three Little Pigs.)
Edna Mode, voiced by Brad Bird
Where you've heard his voice before: Brad Bird — who wrote and directed The Incredibles and Ratatouille, and who is set to write and direct The Incredibles 2 — has also voiced Ambrister Minion in Ratatouille and the monorail announcer in Jurassic World.
Buddy Pine/Syndrome, voiced by Jason Lee
Where you've heard his voice before: The My Name Is Earl actor has voiced Sam and Officer Bays on American Dad!, Charlie on We Bare Bears, and Underdog in Underdog.
Lucius Best/Frozone, voiced by Samuel L. Jackson
Where you've heard his voice before: The Avengers actor has voiced characters in Turbo, Zambezia, Astro Boy, Star Wars: The Clone Wars, Fluke, The Boondocks, and The Proud Family.
Dash Parr, voiced by Spencer Fox
Where you've heard his voice before: The actor — whose above photo was taken in 2004 — voiced both Tim and Jim Possible on Disney's Kim Possible.
Violet Parr, voiced by Sarah Vowell
Mirage, voiced by Elizabeth Peña
Gilbert Huph, voiced by Wallace Shawn
Where you've heard his voice before: The Clueless and Princess Bride actor has voiced characters in The Goofy Movie, BoJack Horseman, Kung Fu Panda: Legends of Awesomeness, Family Guy, and Teacher's Pet, and, of course, he voices Toy Story's Rex.