1. Chris' voice is based on Buffalo Bill from Silence of the Lambs.
2. Peter and Brian stemmed from MacFarlane's 1997 Cartoon Network short Larry & Steve.
3. Family Guy was the first animated program (since The Flintstones) to be nominated for Outstanding Comedy Series at the Emmys.
4. The guy who always calls Peter a "big fat phony" is credited as Holden Caulfield, after the main character of Catcher in the Rye.
5. The Family Guy theme song pays tribute to All in The Family's.
MacFarlane revealed in commentary that he loved the sitcom and wanted to pay homage to the series.
6. After its second cancellation, over 100,000 fans signed a petition to bring it back on air.
7. Death was originally going to be a theme in every episode.
8. Seth MacFarlane had a ticket for a 9/11 plane.
9. American Dad's Roger, Futurama's Bender, and Home Movies' Coach John McGuirk all have cameo appearances in the Star Wars-referencing "It's a Trap" episode.
10. Brian Griffin was named "Stoner of the Year" by High Times in 2009.
11. The main cast makes upwards of $225,000 each per episode.
12. Family Guy has been named the "Worst TV Show of the Week" 44 times by the Parents Television Council.
13. Lois was originally blonde.
14. Quagmire is 66 years old according to his driver's license.
15. Stewie is exactly 1 ¾ years old.
16. Meg was originally voiced by Lacey Chabert, aka Gretchen Wieners.
17. The chicken that fights Peter is named Ernie.
18. Every episode includes at least one character saying "what the hell" to another.
19. The creators pick and choose when Stewie can be heard and understood by his family.
20. Peter changed Meg's full name from Megan to Megatron.
21. Bonnie was pregnant for nearly seven years.
22. William H. Macy auditioned for the role of Brian.
MacFarlane verified this in 2010.