The Duke and Duchess of Sussex will part ways with the Duke and Duchess of Cambridge's charity to form their own foundation, a statement from the Royal Foundation said.
The Royal Foundation said the decision was the outcome of a review into the structure of the charity in its current form, and that the change would allow the couples to focus on causes better aligned with their new households.
"The Duke and Duchess of Cambridge and The Duke and Duchess of Sussex are incredibly proud of what they have achieved together through The Royal Foundation," said a statement outlining the changes.
"Whether through the establishment of The Invictus Games, changing the national conversation on mental health through Heads Together, or setting up Shout, the UK’s first text-based crisis support service, The Foundation’s innovative ethos, ability to convene, and its incubator style has proven to be incredibly powerful and successful."
The Royal Foundation, established by Prince William and Prince Harry in 2009, has been the vehicle for their charitable endeavours, including supplying grants and support for projects of particular interest. Through marriage, Meghan and Kate became patrons for the foundation.
Moving forward, the Royal Foundation will continue to operate with Prince William and Kate at the helm.
The confirmation of the split comes just over a year after the four made their first and only appearance at the inaugural Royal Foundation Forum, outlining their ambitions to work collaboratively.
In the discussion, Meghan told the forum that she had been “working behind the scenes” so that she could “hit the ground running” following her wedding to Prince Harry in May.
She said: "We've all got that same passion to want to make a difference."
The former Suits star was also vocal about her interests in empowering women, having previously campaigned for the United Nations on gender equality and modern slavery.
She said: "I think right now in the climate we are seeing so many campaigns — I mean Me Too and Time's Up — there is no better time ... to really continue to shine a light on women feeling empowered and people really helping to support them, men included in that."
At the same event, Prince Harry joked that the foursome were "stuck together."
There is no confirmation on exactly what type of charitable work the duke and duchess will focus on, but the statement confirmed that the couple would receive "transitional operating support from The Royal Foundation" as it developed.
In addition, both couples will continue to work together on projects in the future, including Heads Together, said the statement.
Prince Harry and Meghan, who welcomed their first child in May, have set about their own path, with the prince taking on more unconventional projects, including his upcoming series on mental health with media mogul Oprah Winfrey for Apple TV.
The decision comes as part of an ongoing process of establishing the Sussex identity, which began with the formal separation of their households in March, when the couple moved from Kensington Palace to Buckingham Palace with the Queen's permission.
The split was also evident online with the launch of their own Instagram account.